Intraperitoneal clearance as a potential biomarker of cisplatin after intraperitoneal perioperative chemotherapy: a population pharmacokinetic study
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چکیده
منابع مشابه
Phase I/pharmacokinetic study of intraperitoneal cisplatin and etoposide.
We administered cisplatin and etoposide by peritoneal dialysis to 39 patients with i.p. malignancies in order to investigate the toxicity, pharmacokinetics, and clinical activity of this 2-drug combination. All patients received i.v. sodium thiosulfate concurrently with the i.p. chemotherapy. Myelosuppression, nausea, vomiting, and malaise were the primary toxicities encountered. The maximum to...
متن کاملPressurized intraperitoneal aerosol chemotherapy (PIPAC) as a neoadjuvant therapy before cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
BACKGROUND Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a novel drug delivery system able to induce regression of peritoneal metastasis (PM) in the salvage situation. The aim of this study was to determine the clinical characteristics, tumor histology, and extent of disease of the patients having undergone cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy ...
متن کامل[Peritoneal gistosis: role of cytoreductive surgery and perioperative intraperitoneal chemotherapy].
Gastrointestinal stromal tumors (GIST) are the most frequent mesenchymal neoplasms of the digestive tract. They are usually seen in patients over the age of 50, with equal sex distribution, with an annual incidence of approximately 5000 in the U.S. They originate from cells of Cajal and the most frequent location is the stomach (60%), followed by the jejunum and ileum (30%). Although they frequ...
متن کاملUpdate on chemotherapeutic agents utilized for perioperative intraperitoneal chemotherapy.
A new strategy currently under evaluation in patients with peritoneal carcinomatosis from gastrointestinal and gynecologic cancers is perioperative intraperitoneal chemotherapy. Although results to date show benefit to carefully selected groups of patients, continued local-regional failure is seen in many treated patients. Continued clinical and laboratory research efforts to improve local-regi...
متن کاملCytoreductive surgery and perioperative intraperitoneal chemotherapy in recurrent ovarian cancer.
BACKGROUND AND AIMS Cytoreductive surgery with perioperative intraperitoneal chemotherapy is another approach for recurrent ovarian cancer. The purpose of the study was to assess the feasibility and the effect of cytoreduction and perioperative intraperitoneal chemotherapy in recurrent ovarian cancer. PATIENTS AND METHODS Twenty-nine women with recurrent ovarian cancer underwent cytoreductive...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2011
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.2011.557